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Olumacostat glasaretil

CAS No. 1261491-89-7

Olumacostat glasaretil ( Olumacostat glasaretil; DRM01B; DRM-01B )

产品货号. M11083 CAS No. 1261491-89-7

A small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC); inhibits de novo lipid synthesis in primary and transformed human sebocytes.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥494 有现货
5MG ¥786 有现货
10MG ¥1191 有现货
25MG ¥2260 有现货
50MG ¥3872 有现货
100MG ¥5646 有现货
200MG ¥8035 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Olumacostat glasaretil
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC); inhibits de novo lipid synthesis in primary and transformed human sebocytes.
  • 产品描述
    A small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC); inhibits de novo lipid synthesis in primary and transformed human sebocytes; reduces saturated and monounsaturated fatty acyl chains across lipid species, including di- and triacylglycerols, phospholipids, cholesteryl esters, and wax esters; significantly reduces hamster ear sebaceous gland size; a pro-drug of TOFA with enhance delivery in vivo.Other Indication Phase 3 Clinical
  • 同义词
    Olumacostat glasaretil; DRM01B; DRM-01B
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Other Indications
  • 适应症
    Other Disease

化学信息

  • CAS Number
    1261491-89-7
  • 分子量
    481.62
  • 分子式
    C26H43NO7
  • 纯度
    >98% (HPLC)
  • 溶解度
    10 mM in DMSO
  • SMILES
    O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)OCC(N(CC(OCC)=O)C)=O
  • 化学全称
    2-Furancarboxylic acid, 5-(tetradecyloxy)-, 2-[(2-ethoxy-2-oxoethyl)methylamino]-2-oxoethyl ester

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Bissonnette R, et al. J Am Acad Dermatol. 2017 Jan;76(1):33-39.
2. Hunt DW, et al. J Invest Dermatol. 2017 Jul;137(7):1415-1423.
3. Melnik BC. J Invest Dermatol. 2017 Jul;137(7):1405-1408.
产品手册
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